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Sonic hedgehog appears to mediate the induction of floor plate by notochord, but in rostral regions sonic hedgehog appears to act cooperatively with another signaling molecule to generate ventral midline cells with rostral properties.
Current experiments are directed at the molecular identification of mesoderm-derived inducing signals at different rostro-caudal levels and the characterization of the response of neuroepithelial cells to such signals.
The lab is developing methods that temporally extend genetic access to this specific population of neurons and permit identification and manipulation of dI1 specific circuits from DRG to brain, using state of the art trans-synaptic viral tracers and gene discovery.
Visualizing the synaptic connections between dI1 cells and specific functional classes of dorsal root ganglion DRG neurons, identifying central targets and the axonal routes of these neurons, and eventually manipulating their activities, will provide novel insights into the functional organization of somatosensory circuits in the developing spinal cord.
Visual System. Somatosensory System. Current Members. Lab Alumni. Enterotoxigenic Escherichia coli expressing F4 fimbriae are the major cause of porcine colibacillosis and are responsible for significant death and morbidity in neonatal and postweaned piglets.
Via the chaperone-usher pathway, F4 fimbriae are assembl Via the chaperone-usher pathway, F4 fimbriae are assembled into thin, flexible polymers mainly composed of the single-domain adhesin FaeG.
The F4 fimbrial system has been labeled eccentric because the F4 pilins show some features distinct from the features of pilins of other chaperone-usher-assembled structures.
In particular, FaeG is much larger than other pilins 27 versus approximately 17 kDa , grafting an additional carbohydrate binding domain on the common immunoglobulin-like core.
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